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Pharmaceutical evaluation and comparison of different brands of metronidazole available in the local market of Peshawar (Pakistan)

Objective: To assess the pharmaceutical quality of different brands of metronidazole manufactured, available and prescribed by the doctors of Peshawar, Pakistan. Methods: Different film-coated metronidazole products manufactured by multinational and national pharmaceutical industries and prescribed... Full description

Main Author: Muhammad Adil
Contributors: Aasif Awan | Author
Sudhair Abbas | Author
Kamran Chishti | Author
Lateef Ahmad | Author
Contained in: Journal of Coastal Life Medicine (01.08.2016)
Journal Title: Journal of Coastal Life Medicine
Fulltext access: Fulltext access (direct link - free access) 10.12980/jclm.4.2016J6-101
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Links: Additional Link (dx.doi.org)
Additional Link (doaj.org)
Additional Link (www.jclmm.com)
Fulltext access (doaj.org)
Fulltext access (doaj.org)
ISSN: 2309-5288
DOI: 10.12980/jclm.4.2016J6-101
Language: English
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.12980/jclm.4.2016J6-101
PPN (Catalogue-ID): DOAJ025127616
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Internes Format
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520 |a Objective: To assess the pharmaceutical quality of different brands of metronidazole manufactured, available and prescribed by the doctors of Peshawar, Pakistan. Methods: Different film-coated metronidazole products manufactured by multinational and national pharmaceutical industries and prescribed by the doctors were collected from Peshawar, Khyber Pakhtunkhwa, Pakistan. Their hysico-chemical properties were assessed, which included friability, hardness, disintegration, dissolution and weight variation tests according to the the United States Pharmacopoeia (USP) standards. Results: All the brands showed a average weight of 5.74 g for 13 tablets (products A–M). Product J had the highest weight and products D and E failed the hardness, friability and disintegration time according to USP standards. Products M, K and G, L failed disintegration test and dissolution test, respectively. Weight variation of all the products proved statistically that they were in accordance with the standards of USP. Conclusions: The study suggested that products A, F, H and J passed all the tests according to the USP standards while the rest of them did not fulfill the standards specification. 
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700 0 |a Sudhair Abbas  |e verfasserin  |4 aut 
700 0 |a Kamran Chishti  |e verfasserin  |4 aut 
700 0 |a Lateef Ahmad  |e verfasserin  |4 aut 
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