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Single-subject grey matter graphs in Alzheimer's disease

Coordinated patterns of cortical morphology have been described as structural graphs and previous research has demonstrated that properties of such graphs are altered in Alzheimer's disease (AD). However, it remains unknown how these alterations are related to cognitive deficits in individuals, as s... Ausführliche Beschreibung

1. Verfasser: Tijms, Betty M
Beteiligte Personen: Möller, Christiane | Verfasser/in
Vrenken, Hugo | Verfasser/in
Wink, Alle Meije | Verfasser/in
de Haan, Willem | Verfasser/in
van der Flier, Wiesje M | Verfasser/in
Stam, Cornelis J | Verfasser/in
Scheltens, Philip | Verfasser/in
Barkhof, Frederik | Verfasser/in
Enthalten in: PloS one Vol. 8, No. 3 (2013), p. e58921
Suche nach Artikeln/Bänden: Suche nach Artikeln/Bänden
Zeitschriftentitel: PloS one
Volltextzugang: Volltextzugang (Direktlink - Open Access) 10.1371/journal.pone.0058921
Links: Volltext (dx.doi.org)
Volltext (www.ncbi.nlm.nih.gov)
ISSN: 1932-6203
Weitere Schlagworte: Aged
Alzheimer Disease
*Brain Mapping
Case-Control Studies
Electroencephalography
Female
Humans
Magnetic Resonance Imaging
Male
Neuroimaging
Psychiatric Status Rating Scales
Severity of Illness Index
Journal Article
Research Support, Non-U.S. Gov't
Sprache: Englisch
Anmerkungen: Date Completed 27.12.2013
Date Revised 20.02.2017
published: Print-Electronic
ErratumIn: PLoS One. 2013;8(9). doi:10.1371/annotation/6a2e6405-ce1d-49e0-a88c-0017c680d597
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Umfang: Online-Ressource
ID (z.B. DOI, URN): 10.1371/journal.pone.0058921
PPN (Katalog-ID): NLM226134725
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Internes Format
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100 1 |a Tijms, Betty M 
245 1 0 |a Single-subject grey matter graphs in Alzheimer's disease  |h Elektronische Ressource 
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500 |a Date Completed 27.12.2013 
500 |a Date Revised 20.02.2017 
500 |a published: Print-Electronic 
500 |a ErratumIn: PLoS One. 2013;8(9). doi:10.1371/annotation/6a2e6405-ce1d-49e0-a88c-0017c680d597 
500 |a Citation Status MEDLINE 
500 |a Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine 
520 |a Coordinated patterns of cortical morphology have been described as structural graphs and previous research has demonstrated that properties of such graphs are altered in Alzheimer's disease (AD). However, it remains unknown how these alterations are related to cognitive deficits in individuals, as such graphs are restricted to group-level analysis. In the present study we investigated this question in single-subject grey matter networks. This new method extracts large-scale structural graphs where nodes represent small cortical regions that are connected by edges when they show statistical similarity. Using this method, unweighted and undirected networks were extracted from T1 weighted structural magnetic resonance imaging scans of 38 AD patients (19 female, average age 72±4 years) and 38 controls (19 females, average age 72±4 years). Group comparisons of standard graph properties were performed after correcting for grey matter volumetric measurements and were correlated to scores of general cognitive functioning. AD networks were characterised by a more random topology as indicated by a decreased small world coefficient (p = 3.53×10(-5)), decreased normalized clustering coefficient (p = 7.25×10(-6)) and decreased normalized path length (p = 1.91×10(-7)). Reduced normalized path length explained significantly (p = 0.004) more variance in measurements of general cognitive decline (32%) in comparison to volumetric measurements (9%). Altered path length of the parahippocampal gyrus, hippocampus, fusiform gyrus and precuneus showed the strongest relationship with cognitive decline. The present results suggest that single-subject grey matter graphs provide a concise quantification of cortical structure that has clinical value, which might be of particular importance for disease prognosis. These findings contribute to a better understanding of structural alterations and cognitive dysfunction in AD 
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653 2 |a Alzheimer Disease  |6 D000544  |a pathology  |6 Q000473  |a *physiopathology  |6 Q000503 
653 2 |a *Brain Mapping  |6 D001931 
653 2 |a Case-Control Studies  |6 D016022 
653 2 |a Electroencephalography  |6 D004569 
653 2 |a Female  |6 D005260 
653 2 |a Humans  |6 D006801 
653 2 |a Magnetic Resonance Imaging  |6 D008279 
653 2 |a Male  |6 D008297 
653 2 |a Neuroimaging  |6 D059906 
653 2 |a Psychiatric Status Rating Scales  |6 D011569 
653 2 |a Severity of Illness Index  |6 D012720 
653 |a Journal Article 
653 |a Research Support, Non-U.S. Gov't 
700 1 |a Möller, Christiane  |e verfasserin  |4 aut 
700 1 |a Vrenken, Hugo  |e verfasserin  |4 aut 
700 1 |a Wink, Alle Meije  |e verfasserin  |4 aut 
700 1 |a de Haan, Willem  |e verfasserin  |4 aut 
700 1 |a van der Flier, Wiesje M  |e verfasserin  |4 aut 
700 1 |a Stam, Cornelis J  |e verfasserin  |4 aut 
700 1 |a Scheltens, Philip  |e verfasserin  |4 aut 
700 1 |a Barkhof, Frederik  |e verfasserin  |4 aut 
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