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Characterization and distribution of mechanically competent mineralized tissue in micropores of ⇋ø-tricalcium phosphate bone substitutes

Although bone formation around and within implants has been intensively studied, the role of pores and pore geometry is still debated. Notwithstanding studies reporting the formation of bone and bone components within pores as small as a few micrometers ('micropores'), bone ingrowth is believed to o... Full description

Main Author: Bohner, Marc
Contributors: Baroud, Gamal | Author
Bernstein, Anke | Author
DÜœbelin, Nicola | Author
Galea, Laetitia | Author
Hesse, Bernhard | Author
Heuberger, Roman | Author
Meille, Sylvain | Author
Michel, Pascal | Author
Rechenberg, Brigitte von | Author
Sague, Jorge | Author
Seeherman, Howard | Author
Contained in: Materials Today Vol. 20, No. 3 (2017), p. 106-115
Fulltext access:
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Links: Additional Link (dx.doi.org)
ISSN: 1369-7021
1873-4103
Additional Keywords: EINDRUECKEN
IMPLANTAT
KERAMIKVERBUNDSTOFF
KNOCHENEINWACHSEN
KNOCHENERSATZWERKSTOFF
KNOCHENWACHSTUM
KOLLAGEN
MAKROPORE
MIKROMETER
MIKROPORE
STEIFIGKEIT
TRICALCIUMPHOSPHAT
DOI: 10.1016/j.mattod.2017.02.002
Language: English
Notes: Copyright: Metadaten: TEMA, Copyright WTI-Frankfurt eG
Copyright: (C) Alle Rechte beim Herausgeber
Physical Description: 10 Seiten, 43 Quellen
ID (e.g. DOI, URN): 10.1016/j.mattod.2017.02.002
PPN (Catalogue-ID): WTI004812034
Note: WTI TEMA DB
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Internes Format
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520 |a Although bone formation around and within implants has been intensively studied, the role of pores and pore geometry is still debated. Notwithstanding studies reporting the formation of bone and bone components within pores as small as a few micrometers ('micropores'), bone ingrowth is believed to only occur in pores larger than 100 Öæm ('macropores'). A thorough analysis of 10 different porous ⇋ø-tricalcium phosphate cylinders (́: 8 mm; L: 13 mm) implanted for 2-24 weeks in an ovine model demonstrates ingrowth of mineralized tissue (MT) in pores as small as 1 Öæm. This tissue contained calcium phosphate, collagen, and interconnected cells. It formed within the first 3-4 weeks of implantation, extended over several hundred micrometers within the ceramic, and contributed to the majority of the early MT formation (including bone) in the defect. The indentation stiffness of the MT-ceramic composite was significantly higher than that of bone and MT-free ceramic. The presented results substantiate the importance of micropores for optimal bone healing, particularly at early implantation times. 
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700 1 |a Bernstein, Anke  |e verfasserin  |4 aut 
700 1 |a DÜœbelin, Nicola  |e verfasserin  |4 aut 
700 1 |a Galea, Laetitia  |e verfasserin  |4 aut 
700 1 |a Hesse, Bernhard  |e verfasserin  |4 aut 
700 1 |a Heuberger, Roman  |e verfasserin  |4 aut 
700 1 |a Meille, Sylvain  |e verfasserin  |4 aut 
700 1 |a Michel, Pascal  |e verfasserin  |4 aut 
700 1 |a Rechenberg, Brigitte von  |e verfasserin  |4 aut 
700 1 |a Sague, Jorge  |e verfasserin  |4 aut 
700 1 |a Seeherman, Howard  |e verfasserin  |4 aut 
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