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Design of a self-cleaning thermoresponsive nanocomposite hydrogel membrane for implantable biosensors

Following implantation of a biosensor, adhesion of proteins and cells and eventual fibrous encapsulation will limit analyte diffusion and impair sensor performance. A thermoresponsive nanocomposite hydrogel was developed as a self-cleaning biosensor membrane to minimize the effect of the host respon... Full description

Contained in: Acta Biomaterialia Vol. 6, No. 8 (2010), p. 2903-2910
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Links: Additional Link (dx.doi.org)
Additional Keywords: DIFFUSION
HYDROGEL
MECHANISCHE-FESTIGKEIT
MEMBRAN
NANOPARTIKEL
PHASENUMWANDLUNG
PHOTOPOLYMERISATION
POLYACRYLAMIDGEL
SILICON:POLYMER
TEMPERATUREINFLUSS
VERBUNDWERKSTOFF
VINYLPYRROLIDON
ZELLADHAESION
DOI: 10.1016/j.actbio.2010.01.039
Notes: Copyright: Metadaten: TEMA, Copyright WTI-Frankfurt eG
Copyright: (C) Alle Rechte beim Herausgeber
Physical Description: 8 Seiten, 5 Bilder, 4 Tabellen, 48 Quellen
ID (e.g. DOI, URN): 10.1016/j.actbio.2010.01.039
PPN (Catalogue-ID): WTI048701009
Note: WTI TEMA DB
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520 |a Following implantation of a biosensor, adhesion of proteins and cells and eventual fibrous encapsulation will limit analyte diffusion and impair sensor performance. A thermoresponsive nanocomposite hydrogel was developed as a self-cleaning biosensor membrane to minimize the effect of the host response and its utility for an optical glucose sensor, demonstrated here. It was previously reported that thermoresponsive nanocomposite hydrogels prepared from photopolymerization of an aqueous solution of N-isopropylacrylamide (NIPAAm) and polysiloxane colloidal nanoparticles released adhered cells with thermal cycling. However, poly(N-isopropylacrylamide) hydrogels exhibit a volume phase transition temperature (VPTT) of approx. 33-34 deg C, which is below body temperature. Thus, the hydrogel would be in a collapsed state in vivo, which would ultimately limit diffusion of the target analyte (e.g., glucose) to the encapsulated sensor. In this study, the VPTT of the nanocomposite hydrogel was increased by introducing N-vinylpyrrolidone (NVP) as a comonomer, so that the hydrogel was in the swollen state in vivo. This thermoresponsive nanocomposite hydrogel was prepared by the photopolymerization of an aqueous solution of NIPAAm, NVP, and polysiloxane colloidal nanoparticles. In addition to a VPTT a few degrees above body temperature, the hydrogel also exhibited good mechanical strength, glucose diffusion, and in vitro cell release upon thermal cycling. Thus, this nanocomposite hydrogel may be useful as a biosensor membrane to minimize biofouling and extend the lifetime and efficiency of implantable glucose sensors and other biosensors. [Copyright Elsevier B.V. Reproduced with permission.] 
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