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Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD : A two-center study

We investigated the ability of cortical and subcortical gray matter (GM) atrophy in combination with white matter (WM) integrity to distinguish behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) and from controls using voxel-based morphometry, subcortical structure segm... Ausführliche Beschreibung

1. Verfasser: Möller, Christiane
Beteiligte Personen: Hafkemeijer, Anne | Verfasser/in
Pijnenburg, Yolande A L | Verfasser/in
Rombouts, Serge A R B | Verfasser/in
van der Grond, Jeroen | Verfasser/in
Dopper, Elise | Verfasser/in
van Swieten, John | Verfasser/in
Versteeg, Adriaan | Verfasser/in
Pouwels, Petra J W | Verfasser/in
Barkhof, Frederik | Verfasser/in
Scheltens, Philip | Verfasser/in
Vrenken, Hugo | Verfasser/in
van der Flier, Wiesje M | Verfasser/in
Enthalten in: NeuroImage. Clinical Vol. 9 (2015), p. 418-29
Suche nach Artikeln/Bänden: Suche nach Artikeln/Bänden
Zeitschriftentitel: NeuroImage. Clinical
Volltextzugang: Volltextzugang (Direktlink) 10.1016/j.nicl.2015.08.022
Links: Volltext (dx.doi.org)
Volltext (www.ncbi.nlm.nih.gov)
ISSN: 2213-1582
Weitere Schlagworte: Aged
Alzheimer Disease
Atrophy
Biomarkers
Cerebral Cortex
Diffusion Tensor Imaging
Female
Frontotemporal Dementia
Gray Matter
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
White Matter
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Alzheimer's disease
Diagnosis
Discriminant analyses
Gray matter atrophy
White matter integrity
Sprache: Englisch
Anmerkungen: Date Completed 06.09.2016
Date Revised 20.02.2017
published: Electronic-eCollection
Cites: Brain. 2011 Sep;134(Pt 9):2502-12. - PMID 21785117
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Umfang: Online-Ressource
ID (z.B. DOI, URN): 10.1016/j.nicl.2015.08.022
PPN (Katalog-ID): NLM254886450
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Internes Format
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100 1 |a Möller, Christiane 
245 1 0 |a Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD  |h Elektronische Ressource  |b A two-center study 
300 |a Online-Ressource 
500 |a Date Completed 06.09.2016 
500 |a Date Revised 20.02.2017 
500 |a published: Electronic-eCollection 
500 |a Cites: Brain. 2011 Sep;134(Pt 9):2502-12. - PMID 21785117 
500 |a Citation Status MEDLINE 
500 |a Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine 
520 |a We investigated the ability of cortical and subcortical gray matter (GM) atrophy in combination with white matter (WM) integrity to distinguish behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) and from controls using voxel-based morphometry, subcortical structure segmentation, and tract-based spatial statistics. To determine which combination of MR markers differentiated the three groups with the highest accuracy, we conducted discriminant function analyses. Adjusted for age, sex and center, both types of dementia had more GM atrophy, lower fractional anisotropy (FA) and higher mean (MD), axial (L1) and radial diffusivity (L23) values than controls. BvFTD patients had more GM atrophy in orbitofrontal and inferior frontal areas than AD patients. In addition, caudate nucleus and nucleus accumbens were smaller in bvFTD than in AD. FA values were lower; MD, L1 and L23 values were higher, especially in frontal areas of the brain for bvFTD compared to AD patients. The combination of cortical GM, hippocampal volume and WM integrity measurements, classified 97-100% of controls, 81-100% of AD and 67-75% of bvFTD patients correctly. Our results suggest that WM integrity measures add complementary information to measures of GM atrophy, thereby improving the classification between AD and bvFTD 
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653 2 |a Atrophy  |6 D001284 
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653 2 |a Cerebral Cortex  |6 D002540  |a pathology  |6 Q000473 
653 2 |a Diffusion Tensor Imaging  |6 D056324 
653 2 |a Female  |6 D005260 
653 2 |a Frontotemporal Dementia  |6 D057180  |a *pathology  |6 Q000473 
653 2 |a Gray Matter  |6 D066128  |a pathology  |6 Q000473 
653 2 |a Humans  |6 D006801 
653 2 |a Magnetic Resonance Imaging  |6 D008279 
653 2 |a Male  |6 D008297 
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653 2 |a Neuropsychological Tests  |6 D009483 
653 2 |a White Matter  |6 D066127  |a *pathology  |6 Q000473 
653 |a Journal Article 
653 |a Multicenter Study 
653 |a Research Support, Non-U.S. Gov't 
653 |a Alzheimer's disease 
653 |a Diagnosis 
653 |a Discriminant analyses 
653 |a Frontotemporal dementia 
653 |a Gray matter atrophy 
653 |a White matter integrity 
653 |a Biomarkers 
700 1 |a Hafkemeijer, Anne  |e verfasserin  |4 aut 
700 1 |a Pijnenburg, Yolande A L  |e verfasserin  |4 aut 
700 1 |a Rombouts, Serge A R B  |e verfasserin  |4 aut 
700 1 |a van der Grond, Jeroen  |e verfasserin  |4 aut 
700 1 |a Dopper, Elise  |e verfasserin  |4 aut 
700 1 |a van Swieten, John  |e verfasserin  |4 aut 
700 1 |a Versteeg, Adriaan  |e verfasserin  |4 aut 
700 1 |a Pouwels, Petra J W  |e verfasserin  |4 aut 
700 1 |a Barkhof, Frederik  |e verfasserin  |4 aut 
700 1 |a Scheltens, Philip  |e verfasserin  |4 aut 
700 1 |a Vrenken, Hugo  |e verfasserin  |4 aut 
700 1 |a van der Flier, Wiesje M  |e verfasserin  |4 aut 
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