Contact
schliessen

Filtern

 

Bibliotheken

Logo der Bibliothek

Siegel TU Braunschweig Universitätsbibliothek Braunschweig
You do not seem to be within the network of Braunschweig University.
As student, researcher or staff member of Braunschweig University you can use the VPN service to gain access to electronic publications.
Alternatively, you can use your university username and password via Shibboleth to gain access to electronic publications with certain publishers. You can find more details in our Blog (in German).

Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin

Communication between acute myeloid leukemia (AML) and the bone marrow microenvironment is known to control disease progression. Therefore, regulation of AML cell trafficking and adhesion to the bone marrow is of significant interest. In this study, we demonstrate that differential expression of the... Full description

Contributors: Marjon, K D
Termini, C M
Karlen, K L
Saito-Reis, C
Soria, C E
Lidke, K A
Gillette, J M
Contained in: International journal of pharmaceutical medicine London [u.a.] : Chapman & Hall Vol. 35, No. 31 (2016), p. 4132
Journal Title: International journal of pharmaceutical medicine
Fulltext access:
Availability is being checked...
Interlibrary loan: Check possibility for interlibrary loan
Links: Volltext (dx.doi.org)
PubMed (www.ncbi.nlm.nih.gov)
Additional Link (search.proquest.com)
DOI: 10.1038/onc.2015.449
Language: English
ID (e.g. DOI, URN): 10.1038/onc.2015.449
1808744626
PPN (Catalogue-ID): OLC1980248834
more publication details ...

Associated Publications/Volumes

  • Associated records are being queried...
more (+)
Internes Format
LEADER 02998naa a2200397 c 4500
001 OLC1980248834
003 DE-601
005 20160816123449.0
008 160816s2016 000 0 eng d
024 7 |a 10.1038/onc.2015.449  |2 doi 
024 8 |a 1808744626 
028 5 2 |a PQ20160815 
035 |a p516-5eeb527185abc9c713c59823bc3e7e916f0b6b18394bd9b465eac4827a4470520 
035 |a 0101737320160000035003104132tetraspanincd82regulatesbonemarrowhomingofacutemye 
040 |b ger  |c GBVCP 
041 0 |a eng 
084 |a pha  |2 natliz 
245 0 0 |a Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin 
520 |a Communication between acute myeloid leukemia (AML) and the bone marrow microenvironment is known to control disease progression. Therefore, regulation of AML cell trafficking and adhesion to the bone marrow is of significant interest. In this study, we demonstrate that differential expression of the membrane scaffold CD82 modulates the bone marrow homing of AML cells. By combining mutational analysis and super-resolution imaging, we identify membrane protein clustering by CD82 as a regulator of AML cell adhesion and bone marrow homing. Cluster analysis of super-resolution data indicates that N-linked glycosylation and palmitoylation of CD82 are both critical modifications that control the microdomain organization of CD82 as well as the nanoscale clustering of associated adhesion protein, N-cadherin. We demonstrate that the inhibition of CD82 glycosylation increases the molecular packing of N-cadherin and promotes the bone marrow homing of AML cells. In contrast, we find that the inhibition of CD82 palmitoylation disrupts the formation and organization of N-cadherin clusters and significantly diminishes bone marrow trafficking of AML. Taken together, these data establish a mechanism where the membrane organization of CD82, through specific posttranslational modifications, regulates N-cadherin clustering and membrane density, which impacts the in vivo trafficking of AML cells. As such, these observations provide an alternative model for targeting AML where modulation of protein organization within the membrane may be an effective treatment therapy to disrupt the bone marrow homing potential of AML cells. 
700 1 |a Marjon, K D 
700 1 |a Termini, C M 
700 1 |a Karlen, K L 
700 1 |a Saito-Reis, C 
700 1 |a Soria, C E 
700 1 |a Lidke, K A 
700 1 |a Gillette, J M 
773 0 8 |i in  |t International journal of pharmaceutical medicine  |d London [u.a.] : Chapman & Hall  |g Vol. 35, No. 31 (2016), p. 4132  |q 35:31<4132  |w (DE-601)05900584X 
856 4 1 |u http://dx.doi.org/10.1038/onc.2015.449  |3 Volltext 
856 4 2 |u http://www.ncbi.nlm.nih.gov/pubmed/26592446 
856 4 2 |u http://search.proquest.com/docview/1808744626 
901 |a OLC 
912 |a SYSFLAG_A 
912 |a GBV_OLC 
912 |a SSG-OLC-PHA 
951 |a AR 
952 |d 35  |j 2016  |e 31  |h 4132